Monoperoxo(picolinato)oxovanadate(V) Brick red solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A potent protein phosphotyrosine phosphatase inhibitor and insulin receptor kinase (IRK) activator. Excellent insulin mimetic in vitro and in vivo. Displays relative specificity as a phosphotyrosine phosphatase inhibitor by inhibiting insulin receptor dephosphorylation to a greater extent than epidermal growth factor receptor dephosphorylation. Purity: ≥90% by 51V-NMR. Ref.: Bevan, A.P., et al. 1995. Am. J. Physiol. 268, E60. Yale, J.F., et al. 1995. Diabetes 44, 1274. Posner, B.I., et al. 1994. J. Biol. Chem. 269, 4596. |
