N-Octyl-3-acetyl-4,5-dimethyl-5-hydroxy-3-pyrrolin-2-one Waxy solid. PACKAGED UNDER INERT GAS. A cell-permeable antitumor agent that induces apoptosis (~40 µM) by directly releasing cytochrome c from mitochondria in human promyelocytic leukemia HL-60 cells. Does not affect mitochondrial transmembrane potential (DYm) in any significant manner. Selectively induces neurite outgrowth in cultured SH-SY5Y, and causes apoptosis in PC12 cells. Purity: ≥95% by NMR. Ref.: Watabe, M., et al. 2000. Cancer Res. 60, 5214. Watabe, M., et al. 1999. Oncogene 18, 5211. Kakeya, H., et al. 1997. J. Med. Chem. 40, 391.
R: 40; S: 36 |
