N6,N6-Dimethyladenine
6-Dimethylaminopurine
6 DMAP White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A puromycin analog that acts as a protein kinase inhibitor. Selectively induces premature mitosis in mammalian cells. Inhibits TNF-a upregulation of ICAM-1, lipolysis, and the activation of JNK/SAPK. Inhibits p34cdc2/cyclin B (IC50 = 300 µM). Induces apoptosis in S-phase-arrested HeLa cells (~5 mM). Purity: ≥98% by HPLC. CAS 938-55-6. Ref.: Ryden, M., et al. 2002. J. Biol. Chem. 277, 1085. Flament, S., et al. 2000. Zygote 8, 3. De Cesaris, P., et al. 1999. J. Biol. Chem. 274, 28978. Ajiro, K., et al. 1996. J. Biol. Chem. 271, 13197. Marino, M.W., et al. 1996. J. Biol. Chem. 271, 28624. Meikrantz, W., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3754. Szollosi, M.S., et al. 1993. J. Cell Sci. 104, 861. Neant, I., and Guerrier, P. 1988. Exp. Cell Res. 176, 68. |
