[1-(3′,4′-Dihydroxybenzoyl)-6,7-dihydroxyisoquinoline-3-carboxylic Acid] Greenish-yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A non-peptide ligand that exhibits high-affinity (Ki ~ 1 - 17 nM) towards all six human insulin-like growth factor-I binding proteins (IGFBPs). Displaces insulin-like growth factor-I (IGF-I) from the IGF-I:IGFBP complex in 3T3 fibroblasts; however, it does not interact with the IGF receptors. Purity: ≥95% by HPLC. Ref.: Chen, C., et al. 2001. J. Med. Chem. 44, 4001. Liu, X.J., et al. 2001. J. Biol. Chem. 276, 32419. |
