3-(4-tert-Butyl-1-pyridino)-1-propane Sulfonate SB256-4T SN2564T White solid. HYGROSCOPIC. A non-detergent sulfobetaine (NDSB) that prevents protein aggregation and facilitates protein-folding, presumably by interacting with the early folding intermediates. Shown to improve the in vitro renaturation efficiency of reduced hen lysozyme (60% enzymatic activity at 0.6 M) and chemically unfolded tryptophan synthase b2 subunit (100% enzymatic activity at 1 M). Purity: ≥98% by TLC and HPLC. Ref.: Expert-Bezancon, N., et al. 2003. Biophys. Chem. 100, 469. |