INCA-6
Inhibitor of NFAT-Calcineurin Association-6 Yellow solid. PROTECT FROM LIGHT. A cell-permeable quinone compound that acts as a potent and selective inhibitor of Calcineurin-NFAT (Nuclear Factor of Activated T cells) signaling. Binds to calcineurin with high affinity (Kd = 800 nM), disrupts its interaction with NFAT and completely blocks its dephosphorylation, nuclear import of NFAT (~40 µM in C1.7W2 T cells), and induction of cytokine mRNAs. Unlike CsA (Cat. No. 239835) and FK506, INCA-6 does not affect calcineurin activity or its downstream signaling. Purity: ≥95% by HPLC. CAS 3519-82-2. Ref.: Roehrl, M.H.A., et al. 2004. Biochemistry 43, 16067. Roehrl, M.H.A., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7554. |
