rhNT-3 Lyophilized solid. PROTECT FROM MOISTURE. Recombinant, human neurotrophin-3 expressed in E. coli. A potent neurotrophic factor that supports the survival of certain CNS neurons. Increases DNA-binding of several transcription factors. Biological activity: Fully biologically active when compared to native NT-3. EC50 = 50 ng/ml for induction of choline acetyltransferase activity in rat basal forebrain primary septal culture cells. Purity: ≥98% by SDS-PAGE. Merck Index: 14, 6487 Ref.: Carter, B.D., et al. 1996. Science 272, 542. Iwata, E., et al. 1996. Biochim. Biophys. Acta 1311, 85. Zhou, X.F., and Rush, R.A. 1994. Brain Res. 643, 162. Hohn, A., et al. 1990. Nature 344, 339. Mainsonpierre, P.C., et al. 1990. Science 247, 1447. |