4-Methyl-N1-(3-phenylpropyl)benzene-1,2-diamine Off-white solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable diamino compound that selectively blocks nuclear translocation of NF-kB p65 and its transcription activity (IC50 = 7.1 µM in a NF-kB reporter assay using RAW 264.7) without affecting IkB degradation. Shown to suppress DNA-binding of NF-kB and downregulate LPS-induced gene expression and apoptotic chromatin condensation. Purity: ≥95% by HPLC. Ref.: Shin, H.M., et al. 2004. FEBS Lett. 571, 50. |