(E)-2-Fluoro-4′-methoxystilbene White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable trans-stilbene Resveratrol (Cat. No. 554325) analog that exhibits much enhanced anti-inflammatory potency, but no anti-oxidant activity. Suppresses LPS-induced COX-2 mRNA expression in BV-2 cells (~46% inhibition at 150 nM) and Shown to be ~130-fold more potent than Resveratrol in inhibiting TNF-a-stimulated NF-kB reporter activity in 293T cells (IC50 = 150 nM). Purity: ≥98% by HPLC. Ref.: Heynekamp, J.J., et al. 2006. J. Med. Chem. 49, 7182. |