1-Carbamoylmethyl-3-carboxy-pyridinium iodide Yellow solid. PROTECT FROM LIGHT. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A cell-permeable nicotinic acid analog that acts as a selective antagonist of NAADP-induced Ca2+ release, while at higher concentrations, also exhibits weak agonistic property towards NAADPR (nicotinic acid adenine dinucleotide phosphate receptor). A weak NAADPR ligand (IC50 = 90 µM in competition binding against 0.2 nM NAADP) that specifically inhibits NAADP-mediated, but not cADPR-, IP3-, or Acetylcholine-evoked, Ca2+ response in sea urchin egg homogenate and in murine pancreatic acinar cells. Purity: ≥98% by HPLC. Ref.: Dowden, J., et al. 2006. Chem. Biol. 13, 659. |
