1,4-Dihydro-2,6-dimethyl-4-(3′-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl-1-methylethyl Ester Light yellow solid. PROTECT FROM LIGHT. An L-type Ca2+ channel blocker. Enhances memory in old or brain-damaged animals. Ameliorates experimental diabetic neuropathy in streptozotocin-induced diabetic rats. Also reported to block TNF-a and LPS-induced iNOS activity (IC50 = 36 pM) in mouse astroglial cells. Purity: >98% by TLC. RTECS US7975500, CAS 66085-59-4. Merck Index: 14, 6551
Ref.: Zhu, D., et al. 1999. Life. Sci. 65, PL 221. Marchetti, C. and Usai, C. 1996. Neurosci. Lett. 207, 77. Kappelle, A.C., et al. 1994. Br. J. Pharmacol. 111, 887. Weiss, J.H., et al. 1994. J. Neurochem. 62, 372. Kappelle, A.C., et al. 1993. Br. J. Pharmacol. 108, 780.
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