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| | Anti-Notch 1 Hamster mAb (8G10) | |  | Cat. No. 491010 | |
| Host: Hamster | | Isotype: IgG | | Immunogen: a recombinant protein consisting of amino acids 1299-1492 of mouse Notch 1 fused to GST | | Form: Liquid | | Formulation: Culture supernatant. | | Preservative: None | | Comments: Recognizes the ~300 kDa Notch 1 protein and its ~230 kDa extracellular fragment. | | Ref.: Robey, E. 1997. Curr. Opin. Mol. Cell Biol. 7, 551. Hsieh, J.J., et al. 1996. Mol. Cell Biol. 16, 952. | |
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 | - Matthew J. LaVoie and Dennis J. Selkoe. (2003) The Notch ligands, Jagged and Delta, are sequentially process by α-secretase and presenilin/γ-secretase and release signaling fragments. Journal of Biological Chemistry 278, 34427-34437.
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