8-Hydroxy-2-methylquinazoline-4-one

Off-white solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A potent inhibitor poly(ADP-ribose) polymerase (PARP; IC₅₀ = 0.40 µM). Has been shown to potentiate the cytotoxicity of the DNA-methylating agent MTIC [5-(3-N-methyltriazen-1-yl)-imidazole-4-carboxamide] and ionizing irradiation in murine L210 leukemia cells. Purity: ≥98% by HPLC. CAS 90417-38-2.

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