White solid. A mixture of A, B, and C isomers. A macrolide antibiotic that inhibits membrane-bound mitochondrial ATPase (F1), preventing phosphoryl group transfer. Induces apoptosis in cultured human lymphoblastoid and other mammalian cells. Purity: ≥90% by HPLC (mixture of A, B, and C isomers). RTECS RK3325000, CAS 1404-19-9. Merck Index: 14, 6833
Ref.: Wolvetang, E.J., et al. 1994. FEBS Lett. 339, 40. Amoroso, S., et al. 1993. J. Pharmacol. Exp. Ther. 264, 515. Brustovetsky, N.N., et al. 1993. FEBS Lett. 315, 233. Nagamune, H., et al. 1993. Biochim. Biophys. Acta 1141, 231.
R: 36/38; S: 26 |
