High Temperature Requirement A2 Inhibitor I
5-[5-(2-Nitrophenyl)furfurylidine]-1,3-diphenyl-2-thiobarbituric Acid Orange solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable furfurylidine-thiobarbituric acid compound that acts as a potent, specific, competitive, and reversible inhibitor of the pro-apoptotic, heat-inducible, mitochondrial serine protease Omi/HtrA2 (IC50 = 9.5 µM for His-Omi134-458). Shows very little activity against various other serine proteases tested (IC50 ≥ 200 µM). Reported to block Omi/HtrA2 induced cell death in caspase-9 (-/-) null fibroblasts. Purity: ≥97% by HPLC. Ref.: Cilenti, L., et al. 2003. J. Biol. Chem. 278, 11489. |
