(RS)-{4-[5-(4-Fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl]pyridin-2-yl}-(1-phenylethyl)amine]
ML3403 Yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable methylsulfanylimidazole compound that acts as a potent, selective, and ATP competitive p38 MAP kinase inhibitor (IC50 = 0.38 µM for p38a). Shown to effectively suppresses LPS-induced cytokine release both in vitro (IC50 = 0.16 and 0.039 µM for TNF-a and IL-1b release, respectively, in human PBMC) and in vivo (ED50 = 1.33 mg/kg for TNF-a release in mouse). When compared with SB 203580 (Cat. No. 559389 and 559398), it exhibits reduced inhibitory activity against cytochrome P450-2D6 isoform and, therefore, is better suited for in vivo use. Purity: ≥98% by HPLC. CAS 581098-48-8. Ref.: Laufer, S.A., et al. 2003. J. Med. Chem. 46, 3230. |
