Fusion Peptide 46

Lyophilized solid. Supplied as a trifluoroacetate salt. HYGROSCOPIC. A synthetic 22-mer (peptide 46), corresponding to the C-terminal amino acid residues 361 - 382 of p53. This peptide is linked to a sequence from the third helix of the Drosophila Antennapedia homeodomain protein to allow cell-permeability. Binds mutant p53 and restores the growth suppressor functions of p53 protein in human tumor cells. Induces apoptosis in human tumor cell lines carrying mutant or wild-type p53 and has no effect in p53 null tumor cell lines. Purity: ≥98% by HPLC. Sold on the basis of peptide content.

H-Gly-Ser-Arg-Ala-His-Ser-Ser-His-Leu-Lys-Ser-Lys-Lys-Gly-Gln-Ser-Thr-Ser-Arg-His-Lys-Lys-Trp-Lys-Met-Arg-Arg-Asn-Gln-Phe-Trp-Val-Lys-Val-Gln-Arg-Gly-OH

Ref.: Selivanova, G., et al. 1999. Mol. Cell Biol. 19, 3395. Selivanova, G., et al. 1997. Nat. Med. 3, 632. Selivanova, G., et al. 1996. Nucleic Acids Res. 24, 3560. Brugidou, J., et al. 1995. Biochem. Biophys. Res. Commun. 214, 685.