ETFSDLWKLL-KKWKMRRNQFWVKVQRG
PNC-28 Lyophilized. Supplied as a trifluoacetate salt. PROTECT FROM LIGHT. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A decapeptide derived from the N-terminal MDM-2 binding domain of p53, residues 17 - 26, and linked to the Antennapedia leader sequence at the C-terminal. Exerts anti-proliferative activities. Directly binds to MDM-2 and induces non-apoptotic cell-death (IC50 = 40 µg/ml in TUC-3 cells) that is independent of p53 activation. Reported to have no effect on the growth of normal cells. Purity: ≥95% by HPLC. H-Glu-Thr-Phe-Ser-Asp-Leu-Trp-Lys-Leu-Leu-Lys-Lys-Trp-Lys-Met-Arg-Arg-Asn-Gln-Phe-Trp-Val-Lys-Val-Gln-Arg-Gly-OH Ref.: Kanovsky, M., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 12438. | 
