2,5-bis-(5-Hydroxymethyl-2-thienyl)-furan
NSC 652287
Reactivation of p53 and Induction of Tumor cell Apoptosis

Crystalline solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable, p53-targeting, tricyclic thiophene derivative that displays antitumor properties. Blocks p53—MDM2 interaction and p53 ubiquitination and induces p53-dependent apoptosis in tumor cells expressing wild-type p53. Shown to restore the tumor suppressor function of p53 by inducing its accumulation in HCT116 colon carcinoma cells (~0.1 µM) and in p53-positive SCID mice xenografted with HCT116 cells (0.1, 1 or 10 mg/kg, ip) in vivo. Purity: ≥97% by HPLC. CAS 213261-59-7.

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