3-Amino-1-hydroxypropylidene-bisphosphonic Acid, 2Na, Pentahydrate

White solid. HYGROSCOPIC. A potent and specific inhibitor of bone resorption that does not cause any significant detrimental effect on bone growth and mineralization at concentrations used. Effective in a variety of conditions characterized by pathologically enhanced bone turnover, including Paget’s disease, hypercalcaemia of malignancy, osteolytic bone metastasis, steroid-induced osteoporosis, and idiopathic osteoporosis. Inhibits breast cancer cell growth by inducing cell death in vitro. Provided in hydrated form, contains five molecules of water. Purity: ≥98% by HPLC. RTECS SZ6522666, CAS 109552-15-0.

Merck Index: 14, 7003
Ref.: Fromigue, O., et al. 2000. J. Bone Miner. Res. 15, 2211. Fitton, A., and McTravish, D. 1991. Drugs 41, 289.
R: 20/21/22-61; S: 36-45