White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable sesquiterpene lactone with anti-inflammatory, antisecretory, and spasmolytic properties. Inhibits the expression of COX-2 and proinflammatory cytokines (TNF-a and IL-1) in LPS-stimulated macrophages. Also inhibits NF-kB and activation of MAP kinase. Purity: ≥97% by TLC. RTECS LY4220000, CAS 20554-84-1. Ref.: Wong, H.R., et al. 1999. Biochem. Biophys. Res. Comm.262, 375. Bork, P.M., et al. 1997. FEBS Lett. 402, 85. Hwang, D., et al. 1996. Biochem. Biophys. Res. Commun. 226, 810. Barsby, R.W., et al. 1992. J. Pharm. Pharmacol. 44, 737. Sumner, H., et al. 1992. Biochem. Pharmacol. 43, 2313. R: 20/21/22-40-42/43; S: 22-36 |