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2′-Amino-3′-methoxyflavone Pale yellow solid. PROTECT FROM LIGHT. Selective and cell-permeable inhibitor of MAP kinase kinase (MEK) that acts by inhibiting the activation of MAP kinase and subsequent phosphorylation of MAP kinase substrates. Pretreatment of PC-12 cells with PD 98059 completely blocks the 4-fold increase in MAP kinase activity produced by nerve growth factor (NGF; IC50 = 2 µM); however, it has no effect on NGF-dependent tyrosine phosphorylation of the p140trk receptor or its substrate Shc and does not block NGF-dependent activation of PI 3-kinase. Blocks LPS-induced activation of TNF-a gene expression. Inhibits cell growth and reverses the phenotype of ras-transformed BALB3T3 mouse fibroblasts and rat kidney cells. Purity: ≥98% by HPLC. CAS 167869-21-8. Ref.: Means, T.K., et al. 2000. J. Leukoc. Biol. 67, 885. Kültz, D., et al. 1998. J. Biol. Chem. 273, 13645. Dudley, D.T., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 7686. Langlois, W.J., et al. 1995. J. Biol. Chem. 270, 25320. Pang, L., et al. 1995. J. Biol. Chem. 270, 13585. Waters, S.B., et al. 1995. J. Biol. Chem. 270, 20883. |
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| DMSO or MeOH | C16H13NO3 | 267.3 |
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