3-(5-Fluoro-3-indolyl)-2-mercapto-(Z)-2-propenoic Acid Orange solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable, non-peptidic, and highly selective calpain inhibitor directed towards the calcium binding sites of calpain. Displays over 20-fold greater selectivity for calpain-1 (Cat. Nos. 208712 and 208713) over calpain-2 (Cat. Nos. 208715 and 208718) (Ki values: 260 nM and 5.33 µM, respectively). Has been shown to prevent cycloheximide-induced apoptosis. Purity: ≥95% by HPLC. Ref.: Squier, M.K., et al. 1999. J. Cell Physiol. 178, 311. Wang, K.K., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 6687. |
