4-(4-Fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)-1H-imidazole Orange-yellow solid. PROTECT FROM LIGHT. A potent, cell-permeable, and selective p38 MAP kinase inhibitor (IC50 = 89 nM). Inhibition of p38 MAP kinase by PD 169316 blocks apoptosis induced by trophic factor withdrawal in non-neuronal and neuronal cell lines. Purity: ≥98% by HPLC. CAS 152121-53-4. Ref.: Nath, R., et al. 2001. Cell Mol. Biol. Lett. 6, 173. Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49. Kummer, J.L., et al. 1997. J. Biol. Chem. 272, 20490. |
