Yellow liquid. Supplied in 4.7% NaOH at 160-200 mM. PROTECT FROM LIGHT. AVOID FREEZE/THAW CYCLES. PACKAGED UNDER INERT GAS. Synthesized from isoamyl nitrite and hydrogen peroxide. Peroxynitrite (ONOO^–) is a cell-permeable strong biological oxidizing agent that reacts with DNA, membrane phospholipids, sulfhydryl groups, and tyrosine. Has been implicated in a variety of pathophysiological conditions including acute respiratory distress syndrome (ARDS), arthritis, atherosclerosis, inflammatory bowel disease, ischemia-reperfusion, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicity, and septic shock. Note: 1 set = 2 x 1 ml.

Ref.: Marla, S.S., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 14243. Sakuma, S., et al. 1997. Biochem. Biophys. Res. Commun. 230, 476. Lymar, S.V., et al. 1996. Biochemistry 35, 7855. Uppu, R.M., and Pryor, W.A. 1996. Methods Enzymol. 269, 322. Ischiropoulos, H., and al-Medhi, A.B. 1995. FEBS Lett. 364, 279.
R: 8-20/22-34; S: 3-28-36/37/39-45