Oxophenylarsine
PAO White solid. A membrane-permeable protein tyrosine phosphatase inhibitor (IC50 = 18 µM). Stimulates 2-deoxyglucose transport in insulin-resistant human skeletal muscle and activates p56lck protein tyrosine kinase. Blocks TNF-a-dependent activation of NF-kB in human myeloid ML-1a cells. PAO inhibits the protease activities of recombinant human caspases as well as endogenous caspases that are active in extracts of pre-apoptotic chicken DU249 cells (S/M extracts). Purity: ≥96% by titration. RTECS CH8100000, CAS 637-03-6. Merck Index: 14, 6949
Ref.: Takahashi, A., et al. 1997. Exp. Cell Res. 231, 123. Carey, J.O., et al. 1995. Diabetes 44, 1995. Le Cabec, V., and Maridonneau-Parini, I. 1995. J. Biol. Chem. 270, 2067. Oetken, C., et al. 1995. Mol. Immunol. 31, 1295. Singh, S., and Aggarwal, B.B. 1995. J. Biol. Chem. 270, 10631.
R: 26/27/28-34-40; S: 26-27-36/37/39-45 |
