4-(6,7-Dimethoxy-4-quinazolinyl)-N-(4-phenoxyphenyl)-1-piperazinecarboxamide

White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable piperazinyl-quinazoline carboxamide compound that acts as a potent, ATP-competitive, and selective inhibitor of PDGF receptor family of tyrosine kinases (IC₅₀ = 0.05 µM for a-PDGFR; 0.08 µM for b-PDGFR; 0.05 µM for c-Kit; 0.23 µM for Flt3). Affects the activities of other kinases only at much higher concentrations (IC₅₀ ≥ 30 µM for EGFR, FGFR, Src, PKA & PKC). Reported to block the PDGF-BB induced proliferation of porcine aorta smooth muscle cells (IC₅₀ = 0.25 µM). Purity: ≥97% by HPLC. CAS 205254-94-0.

Ref.: Matsuno, K., et al. 2003. J. Med. Chem. 46, 4910. Matsuno, K., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3001. Matsuno, K., et al. 2002. J. Med. Chem. 45, 4513. Matsuno, K., et al. 2002. J. Med. Chem. 45, 3057.