PF4 Liquid. In 1.5 M NaCl, 20 mM Tris-HCl, pH 8.3. AVOID FREEZE/THAW CYCLES. Native platelet factor 4 from human platelets. A heparin-binding protein released from a-granules of activated platelets. Binds to the newly formed blood vessels and reduces tumor neovascularization. Purity: ≥95% by SDS. Prepared from platelets that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV. CAS 37270-94-3. M.W. 7800-9000 (monomer). Ref.: Pitsilos, S., et al. 2003. Thromb. Haemost. 90, 1112. Kolber, D.L., et al. 1995. J. Natl. Cancer Inst. 87, 304. Ravanat, C., et al. 1994. Eur. J. Biochem. 223, 203. Cortellaro, M., et al. 1990. Thromb. Res. 58, 571. Sato, Y., et al. 1990. Biochem. Biophys. Res. Commun. 172, 595. |