trans-3,5-Dimethoxy-4′-hydroxystilbene Off-white solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable methoxylated analog of Resveratrol (Cat. No. 554325) that displays antioxidant, antiproliferative, and hypoglycemic properties. Moderately inhibits COX-1 and -2 activities (IC50 = 19.8 µM & 83.9 µM) respectively, induces apoptosis in HL60 cells (IC50 = 70 µM), prevents DMBA-induced preneoplastic lesions (ED50 = 4.8 µM) and decreases plasma glucose level in streptozotocin-induced diabetic rats comparable to that of Metformin. Purity: ≥95% by HPLC. CAS 537-42-8. Ref.: Roberti, M., et al. 2003. J. Med. Chem. 46, 3546. Rimando, A.M., et al. 2002. J. Agric. Food Chem. 50, 3453. Manickam, M., et al. 1997. J. Nat. Prod. 60, 609. |
