PDBu Clear film or white crystalline solid. PACKAGED UNDER INERT GAS. Strong irritant for mouse skin, but only moderately active as a tumor promoter. Activates protein kinase C. Stimulates the phosphorylation of Na+,K+- ATPase, thereby inhibiting its activity. Promotes the expression of inducible NOS in cultured hepatocytes. Commonly used in binding studies or in applications requiring high concentrations of phorbol compounds. Purity: ≥99% by HPLC. RTECS EK7767000, CAS 37558-16-0. Ref.: Fisone, G., et al. 1995. J. Biol. Chem. 270, 2427. Lee, E.J., et al. 1994. Brain Res. 665, 127. Critz, S.D., et al. 1993. J. Neurochem. 60, 1175. Iredale, P.A., et al. 1993. Biochem. Pharmacol. 45, 611. Critz, S.D., and Byrne J.H. 1992. J. Neurophys. 68, 1079. Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937. Ward C.A., and Moffat, M.P. 1992. J. Mol. Cell. Cardiol. 24, 937.
R: 26/27/28-36/37/38-40-41; S: 26-36/37/39-45 |
