PMA
TPA White solid. PACKAGED UNDER INERT GAS. Most commonly-used phorbol ester. Extremely potent mouse skin tumor promoter. Activates protein kinase C in vivo and in vitro, even at nM concentrations. Promotes the expression of inducible NOS in cultured hepatocytes. Activates Ca2+-ATPase and potentiates forskolin-induced cAMP formation. Inhibits apoptosis induced by the Fas antigen, but induces apoptosis in HL-60 promyelocytic leukemia cells. Its binding is reversible. Purity: ≥99% by HPLC. RTECS QH4377000, CAS 16561-29-8. Ref.: Powell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794. Tepper, C.G., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 8443. Oishi, K., and Yamaguchi, M. 1994. J. Cell. Biochem. 55, 168. Macfarlane, D.E., and O’Donnell, P.S. 1993. Leukemia 7, 1846. Ghandi, V.C. and Jones, D.J., 1992. Neuropharmacol. 31, 1101. Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937. Kontny, E., et al. 1992. Eur. J. Pharmacol. 227, 333. Zanaboni, P.B., et al. 1992. J. Appl. Physiol. 73, 2011. Saltis, J., et al. 1991. J. Biol. Chem. 266, 261. Beguinot, L., et al. 1985. Proc. Natl. Acad. Sci. USA 82, 2774. Perchellet, J. 1985. Carcinogenesis 6, 567. Nishizuka, Y. 1984. Science 255, 1365. Mastro, A. 1982. Lymphokines 6, 263.
R: 21-38; S: 26-27-36-45 |
