(bR,dR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-b,d,6-trihydroxy-2-methyl-8[(2S)-2-methyl-1-oxobutoxyl]-1-naphthaleneheptanoic Acid Na 3b-Hydroxycompactin, Na White crystalline solid. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A water-soluble, competitive 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that potently blocks in vivo cholesterol synthesis (Ki ~1 nM). Offers cardioprotection. Also acts as an immunomodulator and an inhibitor of ras p21 isoprenylation. Purity: ≥98% by HPLC. RTECS QJ7185000, CAS 81131-70-6. Merck Index: 14, 7714 Ref.: Kwak, B., et al. 2000. Natl. Med. 6, 1399. Hamelin, B.A., and Turgeon, J., 1998. Trends Pharmacol. Sci. 19, 26. Narisawa, T., et al. 1996. Jpn. J. Cancer Res. 87, 798. Cohen, L.H., et al. 1993. Biochem. Pharmacol. 45, 2203. Koga, T., et al. 1990. Biochim. Biophys. Acta. 1045, 115. Yoshino, G., et al. 1986. Diabetes Res. Clin. Pract. 2, 179 |