2′,4′,6′-Trihydroxy-3-p-hydroxyphenylpropiophenone

White solid. A cell-permeable inhibtor of protein kinase C (IC₅₀ = 20-50 µM). Activates Ca²⁺-activated K⁺ channels in amphibian myelinated nerve fibers at micromolar concentrations. An inhibitor of myo-inositol uptake. Also inhibits L-type Ca²⁺ channel activity. A potent inhibitor of 5′-iodothyronine deiodinase. Antagonist of prostaglandin F_2a receptors linked to phospholipase C in astrocytes. Purity: ≥98% by TLC. CAS 60-82-2.

Merck Index: 14, 7326
Ref.: Berry, G.T., et al. 1994. Pediat. Res. 35, 141. Koh, D.S., et al. 1994. Neurosci. Lett. 165, 167. Morreale de Escobar, G., et al. 1994. Endocrinology 134, 2410. Prevarskaya, N., et al. 1994. Mol. Cell. Neurosci. 5, 699. Kitanaka, J., et al. 1993. J. Neurochem. 60, 704. Wang, X., et al. 1993. Biochem. J. 290, 249. Benga, G., et al. 1992. Eur. J. Cell Biol. 59, 219. Jordan, M.L., and Wright, J. 1991. J. Surg. Res. 50, 569.
R: 36/37/38; S: 26-36