PI-3,4,5-P3, 7NH4
PIP3, Dipalmitoyl- White solid. HYGROSCOPIC. PACKAGED UNDER INERT GAS. Activates Ca2+-insensitive PKC isozymes d, e, and h. Binds to the general receptor for phosphoinositide-1 (GRP1) protein through a plekstrin homology (PH) domain. Also reported to increase the motility of NIH/3T3 cells and produce actin reorganization and membrane ruffling. Purity: ≥98% by NMR. Ref.: Derman, M.P., et al. 1997. J. Biol. Chem. 272, 6465. Klarlund, J.K., et al. 1997. Science 275, 1927. Ireton, K., et al. 1996. Science 274, 780. Toker, A., et al. 1994. J. Biol. Chem. 269, 32358.
R: 36/37/38; S: 26-36 |
