PI-3,5-P2, dipalmitoyl White Lyophilized solid. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A newly discovered phosphoinositide second messenger present in mammalian, plant, and yeast cells. When hyperosmotically stressed, yeast rapidly synthesize PI-3,5-P2 by phosphorylation of PI-3-P at the D-5 position through the action of PI-3,5-OH kinase. PI-3,5-P2 appears to be at the center of a previously uncharacterized regulatory pathway. Purity: ≥95% by NMR. Ref.: Cooke, F.T., et al. 1998. Curr. Biol. 8, 1219. Tolias, K.F., et al. 1998. J. Biol. Chem. 273, 18040. Dove, S.K., et al. 1997. Nature 390, 187. Hinchliffe, K., and Irvine, R. 1997. Nature 390, 123. Whiteford, C.C., et al. 1997. Biochem. J. 323, 597.
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