PIP2 Off-white solid. PROTECT FROM LIGHT. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A component of membrane-bound receptors in association with phospholipase C (PLC). Potently stimulates brain phospholipase D (PLD) activity in vitro. Has been shown to activate protein kinase C (PKC) in the presence of phosphatidylserine and Ca2+. Antagonist of ATP-sensitive potassium (KATP) channels when applied to inside-out membrane patches. Purity: ≥98% by TLC. Ref.: Baukrowitz, T., et al. 1998. Science 282, 1141. Shyng, S.-L., and Nichols, C.G. 1998. Science 282, 1138. Mazzotti, G., et al. 1995. J. Histochem. Cytochem. 43, 181. Liscovitch, M., et al. 1994. J. Biol. Chem. 269, 21403. Chauhan, A., et al. 1991. Biochem. Biophys. Res. Commun. 175, 852. Williamson, J.R. 1986. Hypertension 8, 140. Berridge, M.J., and Irvine, R.F. 1984. Nature 312, 315.
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