m-3M3FBS
2,4,6-Trimethyl-N-(m-3-trifluoromethylphenyl)benzenesulfonamide Off-white solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A novel sulfonamide compound that acts as a cell-permeable and specific activator of phospholipase C (PLC). Shown to stimulate the PLC-mediated intracellular Ca2+ release, inositol phosphates production, and superoxide generation in various cell types. It activates all PLC isotypes (b2, b3, g1, g2, and d1) in vitro, but not heterotrimeric G proteins, PI 3-kinase, or PLD. Purity: ≥95% by HPLC. CAS 200933-14-8. Ref.: Bae, Y.S., et al. 2003. Mol. Pharmacol. 63, 1043. |
