3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone 2-Hydroxy-3-cyano-4-phenyl-6-(3-bromo-6-hydroxyphenyl)pyridine Yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A pyridone compound that acts as an ATP-competitive inhibitor of PIM1 kinase (IC50 = 50 nM) with excellent selectivity over PIM2 and MEK1/2 (IC50 > 20 µM). Purity: ≥90% by HPLC. Ref.: Cheney, I. W., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1679. |