pyridoxal isonicotinoyl hydrazone Yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable, non-toxic tridendate iron (Fe3+) chelator of the aroyl hydrazone class. Even at low concentrations, highly effective in mobilizing Fe3+ from cells and preventing its uptake from transferrin, even at low concentrations. Exhibits similar specificity and binding affinity as Deferoxamine Mesylate (Cat. No. 252750) but has greater access to mitochondrial iron. Also useful for the management of iron overload disease in experimental models. Inhibits the induction of heme containing indoleamine 2,3-dioxygenase activity. Purity: ≥99% by HPLC. CAS 737-86-0. Ref.: Buss, J.L., et al. 2002. Biochem. Pharmacol. 64, 1689. Thomas, S.R., et al. 2001. J. Immunol. 166, 6332. Hermes-Linda, M., et al. 2000. Biochim. Biophys. Acta 1523, 154. Blaha, K., et al. 1998. Blood 11, 4368. Richardson, D.R., and Ponka, P. 1998. J. Lab. Clin. Med. 131, 306. Richardson, D.R.,et al. 1995. Blood 86, 4295. Richardson, D.R., et al. 1994. J. Lab. Clin. Med. 124, 660. Ponka, P., et al. 1988. Biochim. Biophys. Acta 967, 122. Ponka, P., et al. 1984. Biochim. Biophys. Acta 802, 477. Ponka, P., et al. 1979. FEBS Lett. 97, 317. |
