(±)-7-Methyl-2-(morpholin-4-yl)-9-(1-phenylaminoethyl)-pyrido[1,2-a]-pyrimidin-4-one White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable morpholino-pyrimidinone compound that acts as a reversible, ATP-competitive, selective, and highly potent inhibitor of PI 3-Kb (IC50 = 0.005, 0.1, 5, and ≥3.5 µM for -b, -d, -a and -g isoforms, respectively) with little activity against a panel of 15 commonly studied protein kinases even at concentrations as high as 10.0 µM. An excellent tool for studying p110b-dependent responses both in cells in vitro and in animals in vivo. Purity: ≥97% by HPLC. CAS 663619-89-4. Ref.: Chaussade, C., et al. 2007. Biochem. J. 404, 449. Cosemans, J.M, et al. 2006. Blood 108, 3045. Condliffe, A.M., et al. 2005. Blood 106, 1432. Jackson, S.P., et al. 2005. Nat. Med. 11, 507. |
