N,N′-bis[2-(1-Piperidino)ethyl]-3,4,9,10-perylenetetracarboxylic Diimide
Telomerase Inhibitor IV

Dark purple solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A perylene-based ligand that potently inhibits human telomerase by binding to G-quadruplex DNA. The strongest binding site for PIPER appears to be the 3′-boundary of the G-quadruplex. Can also bind non-specifically to nucleic acids. May also be useful as an antiproliferative agent. Purity: ≥95% by HPLC.

Ref.: Han, H., et al. 1999. Biochemistry 38, 6981. Fedoroff, O.Y., et al. 1998. Biochemistry 37, 12367.
R: 20/21/22-40; S: 22-36