3-(4-Chlorophenyl)quinoxaline-5-carboxamide Light brown solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A potent quinoxaline-based PARP inhibitor with a ~5-fold selectivity towards PARP-2 over PARP-1 (IC50 = 7 and 33 nM, respectively). Reported to be brain-permeant and exhibit good pharmacokinetics. Purity: ≥95% by HPLC. Ref.: Ishida, J., et al. 2006. Bioorg. Med. Chem. 14, 1378. Iwashita, A., et al. 2005. FEBS Lett. 579, 1389. |
