Diethyl-1,3,6,8-tetrahydro-1,3,6,8-tetraoxobenzo[lmn][3,8]phenanthroline-2,7-diacetate
PiB Brownish solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable napthalenetetracarboxylic-bisimide compound that displays anti-proliferative properties (IC50 < 5 µM against a panel of human cancer cell lines). Causes cell cycle arrest and acts as a potent, selective, reversible, competitive, active site binding inhibitor of Pin1/Par14 PPIase (peptidyl prolyl cis-trans isomerase) activity (IC50 ~ 1.5 µM). Does not bind to DNA or functions as a topoisomerase I inhibitor. Purity: ≥95% by NMR. Ref.: Uchida, T., et al. 2003. Chem. Biol. 10, 15. |
