Z-GPFL-CHO White lyophilized solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A tetrapeptide aldehyde that acts as a highly selective and potent proteasomal inhibitor (Ki = 1.5 µM for branched chain amino acid preferring, 2.3 µM for small neutral amino acid preferring, and 40.5 µM for chymotrypsin-like activities; IC50 = 3.1 µM for peptidyl-glutamyl peptide hydrolyzing activity). Shown to be a weak inhibitor of trypsin-like proteasomal activity. Purity: ≥95% by HPLC. Z-Gly-Pro-Phe-Leu-CHO Ref.: Oberdorf, J., et al. 2001. Biochemistry 40, 13397. Cardozo, C., et al. 1999. Biochemistry 38, 9768. Eleuteri, A.M., et al. 1997. J. Biol. Chem. 272, 11824. Orlowski, M., et al. 1997. Biochemistry 36, 13946. Vinitsky, A., et al. 1994. J. Biol. Chem. 269, 29860. |
