PRMT Inhibitor, AMI-1 Solid. PROTECT FROM LIGHT. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A cell-permeable, symmetrical sulfonated urea compound that acts as a potent, specific and non-AdoMet (S-adenosyl-L-methionine, SAM)-competitive inhibitor of protein arginine N-methyltransferases (PRMTs; IC50 = 8.81 µM for PRMT1 and 3.03 for yeast-RMT1p) with minimal effect on lysine methyltransferases. Inhibits nuclear receptor reporter gene activation in MCF-7 cells, and HIV-1 RT polymerase (IC50 = 5 µM). Purity: ≥95% by HPLC. Ref.: Cheng, D., et al. 2004. J. Biol. Chem. 279, 23892. Skillman, A.G., et al. 2002. Bioorg. Chem. 30, 443. |
