3-(3,5-Dibromo-4-hydroxy-benzoyl)-2-ethyl-benzofuran-6-sulfonicacid-(4-(thiazol-2-ylsulfamyl)-phenyl)-amide White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable sulfanamido-benzbromarone compound that acts as a selective, reversible and non-competitive allosteric inhibitor of PTP1B (IC50 = 4 µM and 8 µM for PTP1B403 and PTP1B298, respectively). Binds to a novel site away from the catalytic pocket and inhibits PTP1B activity by preventing closure of the WPD loop. Purity: ≥95% by HPLC. Ref.: Wiesmann, C., et al. 2004. Nat. Struct. Mol. Biol. 11, 730. | 
