a-Bromo-4-methoxyacetophenone
4-Methoxyphenacyl Br
Protein Tyrosine Phosphatase Inhibitor II White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A potent, cell-permeable, and covalent protein tyrosine phosphatase (PTP) inhibitor. Binds to SHP-1 (DSH2), the catalytic domain of the SH2 domain-containing phosphatase SHP-1, with lower affinity than PTP Inhibitor I (Cat. No. 540200) (Ki = 128 µM versus Ki = 43 µM) but with a higher kinact (2.4 min-1 versus 0.4 min-1). The inhibition can be reversed by irradiation of the inactivated PTP at 350 nm. Purity: ≥98% by HPLC. CAS 2632-13-5. Ref.: Arabaci, G., et al. 1999. J. Am. Chem. Soc. 121, 5085.
R: 34-36/37; S: 26-27-28-36/37/39 |
