bis(4-Trifluoromethylsulfonamidophenyl)-1,4-diisopropylbenzene
Protein Tyrosine Phosphatase Inhibitor IV White to off-white solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. An uncharged, 1,4-di-substituted, phenyl-linked bis-trifluoromethylsulfonamido (TFMS) phosphate mimetic that acts as a potent, reversible, competitive, and active-site directed inhibitor of protein tyrosine phosphatases (PTP; IC50 = 1.8, 2.5, 8.4, 13, 20, 6.4, and 6.7 µM for SHP-2, PTP1B, PTP-e, PTP-Meg-2, PTP-s, PTP-b, and PTP-µ, respectively). Purity: ≥95% by HPLC. Ref.: Huang, P., et al. 2003. Bioorg. Med. Chem. 11, 1835. |
