N-(9,10-Dioxo-9,10-dihydro-phenanthren-2-yl)-2,2-dimethyl-propionamide
Protein Tyrosine Phosphatase CD45 Inhibitor
PTPase CD45 Inhibitor Red-violet solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable, potent, selective, competitive, and reversible inhibitor of CD45 (IC50 = 200 nM or 3.8 µM using pNPP or phosphorylated Ick505 peptide as a substrate, respectively). Does not effectively inhibit PTPIB (IC50 <30 µM using phosphorylated Ick505 peptide as a substrate). The phenanthrenedione group does not function as a thiol oxidizing agent. Purity: ≥ 97% by HPLC. Ref.: Urbanek, R.A., et al. 2001. J. Med. Chem. 44, 1777. |
