2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine
Shh Signaling Agonist Beige solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable 2,6,9-trisubstituted purine compound that induces osteoblast differentiation of multipotent mesenchymal progenitor cells C3H10T1/2 (EC50 = 1 µM) and lineage-committed preosteoblasts MC3T3-E1. Its effect can be synergized with that of BMP-4 (bone morphogenetic protein-4) and has been shown to induce transdifferentiation even in preadipocytes and myoblasts. Reported to induce osteogenesis by activation of the Hedgehog signaling pathway. Purity: ≥98% by HPLC. Ref.: Wu, X., et al. 2004. Chem. Biol. 11, 1229. Wu, X., et al. 2002. J. Am. Chem. Soc. 124, 14520. |
